Engaging Surround Inhibition Using SCS-Based Fast-Acting Sub-Perception Therapy: 24-Month Outcomes from a Prospective Study

Thursday, November 13, 2025

8:23 AM - 8:31 AM CT

Location: 301 - 302

Introduction: Novel Fast-Acting Sub-Perception Therapy (FAST) has demonstrated robust and rapid (seconds to minutes) onset of analgesia in chronic pain patients implanted with Spinal Cord Stimulation (SCS) systems (1-3). Per preclinical data, FAST-SCS is thought to specifically engage the Surround Inhibition mechanism of action to mediate the suppression of chronic pain (4). This study reports the clinical effectiveness of patients who prefer FAST in a prospective, multicenter, single-arm assessment and in this report describe long-term outcomes.

Presenting Author(s)

Magdalena Anitescu, MD, PhD (she/her/hers)

Professor
University of Chicago Medical Center, Illinois, United States

Co-Author(s)

EL

Eric Loudermilk, MD

Pain Management Physician
Piedmont Comprehensive Pain Management Group, United States
DT

Drew M. Trainor, DO, MS

Pain Management Physician
The Denver Spine and Pain Institute, United States
JN

John Noles, MD

Pain Management Physician
Spine and Pain Specialists, United States
JL

Jennifer Lee, MD

Pain Management Physician
Acute and Chronic Pain Therapies, United States
Sayed E. Wahezi, MD (he/him/his)

Pain Management Physician
Montefiore Multidisciplinary Pain Program
New Rochelle, New York, United States
DW

Derron Wilson, MD

Pain Management Physician
Goodman Campbell Brain and Spine, United States

Submitting Author(s)

EG

Edward Goldberg, MD

Director, Clinical Research
Boston Scientific
Valencia, California, United States