EEG-Detected Low Frequency Oscillations in the Medial Orbitofrontal Cortex Are Linked to Widespread Hyperalgesia

Friday, November 14, 2025

1:45 PM - 1:53 PM CT

Location: 301 - 302

Introduction:

Widespread hyperalgesia, common in chronic low back pain (cLBP) and chronic pancreatitis (CP), is linked to severe pain and poor response to peripheral treatments, yet its central mechanisms remain unclear. Neuroimaging implicates the medial orbitofrontal cortex (mOFC) in top-down pain modulation. This study investigates whether mOFC oscillatory activity during noxious stimulation represents a shared neurophysiological mechanism of widespread hyperalgesia across chronic pain conditions and whether it can predict treatment outcomes.

Submitting Author(s)

MR

Mika Rockholt, MD PhD

Postdoctoral Research Fellow, Staff Physician
NYU Langone Health
New York, New York, United States

Co-Author(s)

HP

Hyung Park, PhD

Assistant Professor
Division of Biostatistics, NYU Grossman School of Medicine, United States
ZC

Zhe Sage Chen, PhD

Associate Professor
Department of Neuroscience, NYU Grossman School of Medicine, United States
XJ

Xiaomeng Ju, PhD

Postdoctoral Research Fellow
Division of Biostatistics, NYU Grossman School of Medicine, United States
GK

George Kenefati, n/a

Senior Data Analyst
Department of Anesthesiology, NYU Grossman School of Medicine, United States
RW

Rachel Wu, n/a

Data Associate
Department of Anesthesiology, NYU Grossman School of Medicine, United States
TG

Tamas Gonda, MD

Professor, Physician (Gastroenterology)
Department of Medicine, NYU Grossman School of Medicine, United States
JW

Jing Wang, MD PhD

Professor, Vice Chair Research
Department of Neuroscience and Anesthesiology, NYU Grossman School of Medicine, United States

Presenting Author(s)

LD

Lisa Doan, MD

Associate Professor
Department of Anesthesiology, NYU Grossman School of Medicine, United States