Evaluating the Risk of Methadone and QTc Interval Prolongation in an Oncologic Population

Friday, November 14, 2025

2:09 PM - 2:17 PM CT

Location: 301 - 302

Introduction: Methadone is commonly used as an alternative to other opioids for managing cancer-related pain. High-dose methadone ( >100 mg/day), primarily in opioid dependence treatment, has been associated with QTc prolongation. The cardiovascular side effects of methadone at lower doses, as used in cancer pain management, remain less well characterized.

Submitting Author(s)

DL

Daniel Y. Li, BA

Medical Student
McGovern Medical School at UTHealth Houston
Houston, Texas, United States

Co-Author(s)

SK

Serena Kim, BA

Medical Student
Baylor College of Medicine, United States

SJ

Saba Javed, MD

Associate Professor
Department of Pain Medicine, Division of Anesthesiology, Critical Care Medicine and Pain Medicine, The University of Texas MD Anderson Cancer Center
Houston, Texas, United States

BH

Billy Huh, MD, PhD

Professor
Department of Pain Medicine, Division of Anesthesiology, Critical Care Medicine and Pain Medicine, The University of Texas MD Anderson Cancer Center, United States