Skip to main content
ASRAFALL25 Main banner
Icon Legend
Presentation Icons
Ticket Required
Ticket Required

ePosters

Advancing Cancer Pain Management

Preliminary results from Antagonism of Endogenous Opioids – Use in Interpretation of Injections [AEOUI2] pilot study

Thursday, November 13, 2025
1:30 PM - 1:35 PM CT
Introduction:

Patients with lower back pain sometimes undergo lumbar medial branch blocks (LMBB) to predict response to lumbar medial branch radiofrequency neurotomy (LMBRN). Surprisingly, some patients with analgesia after LMBB don’t respond to LMBRN. This phenomenon may be caused by placebo responses linked to endogenous opioids (EOs).1 This study aims to use high-dose naloxone to detect and quantify the placebo effect when performing LMBB.2

    Submitting Author(s)

  • GA

    Gary Allen, MD

    PGY-3 Resident Physician
    Vanderbilt University Medical Center
    Nashville, Tennessee, United States

    • Co-Author(s)

  • WR

    W. Evan Rivers, DO

    Associate Professor
    Vanderbilt University Medical Center, United States