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ePosters

Lifelong Learning and Career Development

Synaptic activity of specific central amygdala neurons is differentially affected by pain and sphingolipid receptor signaling.

Friday, November 14, 2025
4:20 PM - 4:25 PM CT
Location: Lone Star Salon D - E
Introduction:

The central nucleus of the amygdala (CeA), or the “nociceptive amygdala” is key in chronic pain processing1,2. A major subclass of CeA neurons expressing corticotropin-releasing hormone (CRH; CeA-CRH neurons) is sensitized in acute, but not chronic, neuropathic pain3. Signal transduction regulation of CeA-CRH neurons remains poorly understood, which we addressed by investigating sphingosine-1-phosphate (S1P). S1P has region-specific effects on pain in the CNS4,5. I hypothesized S1P regulates synaptic activity onto CeA-CRH neurons in neuropathic pain.

    Submitting Author(s)

  • RH

    Regan C. Hines, n/a

    PhD Candidate
    Indiana University School of Medicine Department of Pharmacology & Toxicology
    Indianapolis, Indiana, United States

    • Co-Author(s)

  • PS

    Patrick L. Sheets, PhD

    Associate Professor
    Indiana University School of Medicine Department of Pharmacology & Toxicology, United States