Inflammatory Biomarkers in Chronic Pain Predict Psychiatric Morbidity: A Multi-Network EHR Cohort

Friday, November 14, 2025

9:53 AM - 10:01 AM CT

Location: Griffin Hall - Screen 06

Introduction: There is an increased recognition of the role of systemic inflammation, mediated through inflammatory markers like IL-6, CRP, in pathophysiology of psychiatric disorders like depression, schizophrenia and substance abuse. While bidirectional influence of chronic pain and psychiatric morbidity is also understood, large-scale, real-world estimates on this topic remain limited. We aim to bridge this gap through a cohort study using TriNetX.

Submitting Author(s)

AV

Abhinav Singh Verma, MD

PGY3 Resident in Psychiatry
Case Western Reserve University/ MetroHealth
Cleveland, Ohio, United States

Co-Author(s)

AP

Anjali Pathak, MD

Resident PGY1
CCF Main campus, Ohio, United States

VS

Vasudha Sharma, MD

Hospitalist
Dayanand Medical College & Hospital, India

RG

Rishab Gupta, MD

Associate Psychiatrist
Brigham & Women's Faulkner Hospital, United States