Therapeutic Potential of Calcitonin Gene-related Peptide Antagonists in Spinal Cord Injury Related Neuropathic Pain: A Case Report
Friday, November 14, 2025
3:38 PM - 3:46 PM CT
Location: Griffin Hall - Screen 02
Introduction: Neuropathic pain (NP) is common after spinal cord injury (SCI) [1]. Calcitonin gene-related peptide (CGRP) is a neuropeptide expressed in C-fibers and Aδ afferents transmitting pain to the spinal cord [2,3]. Animal and human studies [2,4] demonstrate new aberrant immunoreactive CGRP-fiber sprouting within the dorsal horn after SCI, facilitating maladaptive nociceptive input [4,5]. In animal models of SCI, this sprouting is associated with allodynia and hyperalgesia [2]. CGRP antagonists (CGRPi) are FDA-approved for migraine headaches.
