Psilocybin as a Therapy for Refractory Chronic Pain

Thursday, November 13, 2025

9:03 AM - 9:11 AM CT

Location: 301 - 302

Introduction:

Refractory chronic pain, including neuropathic and complex regional pain syndrome (CRPS), is pain resistant to conventional therapies. Psilocybin, a serotonin 2A agonist, may disrupt maladaptive pain circuits via neuroplasticity and anti-inflammatory effects. This abstract evaluates psilocybin’s efficacy, dosing, and safety in pain management, aiming to advance treatment modalities for chronic pain and to enhance functional outcomes.

Submitting Author(s)

VV

Vineet Vemulapally, DO

Physical Medicine and Rehabilitation Resident
OBH, United States

Co-Author(s)

PJ

Panayotis Jusakos, MD

Physical Medicine and Rehabilitation Resident
One Brooklyn Health
Orlando, Florida, United States
RA

Roberto Andrade, MD

Physical Medicine and Rehabilitation Resident
OBH, United States
TR

Tishawn Ross, MD

Physical Medicine and Rehabilitation Resident
OBH
Brooklyn, New York, United States