Treatment of Acute Postoperative Pain in Chronic Pain Patient Using Suzetrigine, a Novel Non-Opioid Analgesic

Friday, November 14, 2025

12:06 PM - 12:14 PM CT

Location: 301 - 302

Introduction:

There has been limited progress in developing non-opioid medications for acute perioperative pain. Suzetrigine (VX-548) is a selective sodium channel blocker that was recently approved for the treatment of acute postoperative pain (Jones, 2023; Keam, 2025). Trials have shown that it reduces moderate-to-severe acute pain comparably to hydrocodone/acetaminophen (Bertoch, 2025). We present a case of acute postoperative pain in a chronic pain patient with bilateral above-knee amputations (AKAs) who responded well to suzetrigine.

Submitting Author(s)

DP

Derek Paradis, MD.

Resident Physician
Anesthesia Department - Walter Reed National Military Medical Center
Bethesda, Maryland, United States

Co-Author(s)

VL

Vivian Lee, MD., MS.

Fellow
Pain Management Department - Walter Reed National Military Medical Center, United States
SW

Sara Wilson, MD.

Program Director
Pain Management Department - Walter Reed National Military Medical Center, United States