Suzetrigine Compared with NSAIDs in Chronic Hip/Knee Osteoarthritis: A Retrospective Cohort Analysis

Friday, November 14, 2025

1:45 PM - 1:50 PM CT

Location: Lone Star Salon D - E

Introduction: Hip and knee osteoarthritis (OA) is a leading cause of chronic pain, functional impairment, and analgesic reliance. Although NSAIDs are commonly used, gastrointestinal, cardiovascular, and renal toxicities limit long-term use [1,2]. Amid the opioid epidemic, safer alternatives are critical. Suzetrigine, a selective NaV1.8 inhibitor, provides effective, well-tolerated analgesia in acute pain models (abdominoplasty, bunionectomy) by modulating peripheral nociception [3-5]. We evaluated its real-world efficacy versus NSAIDs on pain, opioid use, and safety in chronic OA.

Submitting Author(s)

AP

Aagna Patel, DO

Resident Physician
Larkin Community Hospital - South Miami
Miami, Florida, United States

Co-Author(s)

MG

Maria Cecilia Guerrero, DO

Resident Physician
Larkin Community Hospital - South Miami, United States
SS

Sahil S. Shah, DO

Resident Physician
Larkin Community Hospital - Palm Springs
Miami Lakes, Florida, United States
RS

Roshan Santhosh, DO

Resident Physician
Larkin Community Hospital - South Miami, United States