Cryoneurolysis for management of limb spasticity: A systematic review

Friday, November 14, 2025

10:17 AM - 10:25 AM CT

Location: Griffin Hall - Screen 08

Introduction: Damage to upper motor neurons frequently results in spasticity, a condition that increases muscle tone and stiffness due to hyperexcitable stretch reflexes. Current treatment modalities include intrathecal treatments, oral antispasticity medicines, and botulinum toxin injections. However, these are sometimes limited by their invasive nature, adverse effects, and temporary effectiveness. A new technique for lowering spasticity is cryoneurolysis, a percutaneous nerve block that uses extremely low temperatures to induce pain relief and nerve regeneration.

Submitting Author(s)

JC

Jensen C. Clark, BS

Medical Student
Rowan Virtua School of Osteopathic Medicine
sicklerville, New Jersey, United States

Co-Author(s)

AM

Aarti Mehta, BS

Medical Student
Rowan-Virtua School of Osteopathic Medicine, United States
KD

Kunal Damaraju, BS

Medical Student
Rowan-Virtua School of Osteopathic Medicine, United States
BG

Brandon J. Goodwin, DO

PM&R Resident (PGY-2)
Johns Hopkins University, United States